Abstract Pratylenchus coffeae is a parasitic nematoda that infected the roots of some plants, one of them is coffee.The Infection of Pratylenchus coffeae cause root tissue damage that led to root lession and make root become rotten, it will interfere the ability of roots to absorb water and nutrients in the soil which resulted in the growth of plan
Improving Expression of Pepsinogen A from Homo sapiens in Aspergillus niger by Using a Multi-Copy Gene Knock-in Strategy
Pepsinogen A (PGA) plays an important role in the treatment of human gastrointestinal diseases.At present, PGA is mainly extracted from pig stomach, so its source is very limited and its price is very expensive.Production of PGA by microbial fermentation using an engineered strain with high PGA yield would be an ideal solution.This paper presents a
Toward dual hematopoietic stem-cell transplantation and solid-organ transplantation for sickle-cell disease
Abstract: Sickle-cell disease (SCD) leads to recurrent vaso-occlusive crises, chronic end-organ damage, and resultant physical, psychological, and social disabilities.Although hematopoietic stem-cell transplantation (HSCT) is potentially curative for SCD, this procedure is associated with well-recognized morbidity and mortality and thus is ideally